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论文题目: The PRC2-binding long non-coding RNAs in human and mouse genomes are associated with predictive sequence features
英文论文题目: The PRC2-binding long non-coding RNAs in human and mouse genomes are associated with predictive sequence features
第一作者: Tu, SQ; Yuan, GC; Shao, Z
英文第一作者: Tu, SQ; Yuan, GC; Shao, Z
联系作者: Shao, Z (reprint author), Chinese Acad Sci, Key Lab Computat Biol, Collaborat Innovat Ctr Genet & Dev Biol, Max Planck Soc Partner Inst Computat Biol,Shangha, Shanghai 200031, Peoples R China.
英文联系作者: Shao, Z (reprint author), Chinese Acad Sci, Key Lab Computat Biol, Collaborat Innovat Ctr Genet & Dev Biol, Max Planck Soc Partner Inst Computat Biol,Shangha, Shanghai 200031, Peoples R China.
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发表年度: 2017
卷: 7
期:
页码: 41669
摘要: Recently, long non-coding RNAs (lncRNAs) have emerged as an important class of molecules involved in many cellular processes. One of their primary functions is to shape epigenetic landscape through interactions with chromatin modifying proteins. However, mechanisms contributing to the specificity of such interactions remain poorly understood. Here we took the human and mouse lncRNAs that were experimentally determined to have physical interactions with Polycomb repressive complex 2 (PRC2), and systematically investigated the sequence features of these lncRNAs by developing a new computational pipeline for sequences composition analysis, in which each sequence is considered as a series of transitions between adjacent nucleotides. Through that, PRC2-binding lncRNAs were found to be associated with a set of distinctive and evolutionarily conserved sequence features, which can be utilized to distinguish them from the others with considerable accuracy. We further identified fragments of PRC2-binding lncRNAs that are enriched with these sequence features, and found they show strong PRC2-binding signals and are more highly conserved across species than the other parts, implying their functional importance.
英文摘要: Recently, long non-coding RNAs (lncRNAs) have emerged as an important class of molecules involved in many cellular processes. One of their primary functions is to shape epigenetic landscape through interactions with chromatin modifying proteins. However, mechanisms contributing to the specificity of such interactions remain poorly understood. Here we took the human and mouse lncRNAs that were experimentally determined to have physical interactions with Polycomb repressive complex 2 (PRC2), and systematically investigated the sequence features of these lncRNAs by developing a new computational pipeline for sequences composition analysis, in which each sequence is considered as a series of transitions between adjacent nucleotides. Through that, PRC2-binding lncRNAs were found to be associated with a set of distinctive and evolutionarily conserved sequence features, which can be utilized to distinguish them from the others with considerable accuracy. We further identified fragments of PRC2-binding lncRNAs that are enriched with these sequence features, and found they show strong PRC2-binding signals and are more highly conserved across species than the other parts, implying their functional importance.
刊物名称: Scientific Reports
英文刊物名称: Scientific Reports
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学科: Multidisciplinary Sciences
英文学科: Multidisciplinary Sciences
影响因子: 4.259
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论文类别: Article
英文论文类别: Article
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