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论文题目: Lipidome determinants of maximal lifespan in mammals
英文论文题目: Lipidome determinants of maximal lifespan in mammals
第一作者: Bozek, K; Khrameeva, EE; Reznick, J; Omerbasic, D; Bennett, NC; Lewin, GR; Azpurua, J; Gorbunova, V; Seluanov, A; Regnard, P; Wanert, F; Marchal, J; Pifferi, F; Aujard, F; Liu, Z; Shi, P; Paabo, S; Schroeder, F; Willmitzer, L; Giavalisco, P; Khaitovich, P
英文第一作者: Bozek, K; Khrameeva, EE; Reznick, J; Omerbasic, D; Bennett, NC; Lewin, GR; Azpurua, J; Gorbunova, V; Seluanov, A; Regnard, P; Wanert, F; Marchal, J; Pifferi, F; Aujard, F; Liu, Z; Shi, P; Paabo, S; Schroeder, F; Willmitzer, L; Giavalisco, P; Khaitovich, P
联系作者: Bozek, K; Khaitovich, P (reprint author), CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.
英文联系作者: Bozek, K; Khaitovich, P (reprint author), CAS MPG Partner Inst Computat Biol, CAS Key Lab Computat Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.
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发表年度: 2017
卷: 7
期:
页码: 5
摘要: Maximal lifespan of mammalian species, even if closely related, may differ more than 10-fold, however the nature of the mechanisms that determine this variability is unresolved. Here, we assess the relationship between maximal lifespan duration and concentrations of more than 20,000 lipid compounds, measured in 669 tissue samples from 6 tissues of 35 species representing three mammalian clades: primates, rodents and bats. We identify lipids associated with species' longevity across the three clades, uncoupled from other parameters, such as basal metabolic rate, body size, or body temperature. These lipids clustered in specific lipid classes and pathways, and enzymes linked to them display signatures of greater stabilizing selection in long-living species, and cluster in functional groups related to signaling and protein-modification processes. These findings point towards the existence of defined molecular mechanisms underlying variation in maximal lifespan among mammals.
英文摘要: Maximal lifespan of mammalian species, even if closely related, may differ more than 10-fold, however the nature of the mechanisms that determine this variability is unresolved. Here, we assess the relationship between maximal lifespan duration and concentrations of more than 20,000 lipid compounds, measured in 669 tissue samples from 6 tissues of 35 species representing three mammalian clades: primates, rodents and bats. We identify lipids associated with species' longevity across the three clades, uncoupled from other parameters, such as basal metabolic rate, body size, or body temperature. These lipids clustered in specific lipid classes and pathways, and enzymes linked to them display signatures of greater stabilizing selection in long-living species, and cluster in functional groups related to signaling and protein-modification processes. These findings point towards the existence of defined molecular mechanisms underlying variation in maximal lifespan among mammals.
刊物名称: SCIENTIFIC REPORTS
英文刊物名称: SCIENTIFIC REPORTS
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学科: Multidisciplinary Sciences
英文学科: Multidisciplinary Sciences
影响因子: 4.259
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论文类别: Article
英文论文类别: Article
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