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论文题目: Identification of the core regulators of the HLA I-peptide binding process
英文论文题目: Identification of the core regulators of the HLA I-peptide binding process
第一作者: Zhang, YH; Xing, ZH; Liu, CL; Wang, SP; Huang, T; Cai, YD; Kong, XY
英文第一作者: Zhang, YH; Xing, ZH; Liu, CL; Wang, SP; Huang, T; Cai, YD; Kong, XY
联系作者: Huang, T; Kong, XY (reprint author), Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Chinese Acad Sci, Shanghai 200031, Peoples R China.
英文联系作者: Huang, T; Kong, XY (reprint author), Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Chinese Acad Sci, Shanghai 200031, Peoples R China.
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发表年度: 2017
卷: 7
期:
页码: 42768
摘要: During the display of peptide/human leukocyte antigen (HLA)-I complex for further immune recognition, the cleaved and transported antigenic peptides have to bind to HLA-I protein and the binding affinity between peptide epitopes and HLA proteins directly influences the immune recognition ability in human beings. Key factors affecting the binding affinity during the generation, selection and presentation processes of HLA-I complex have not yet been fully discovered. In this study, a new method describing the HLA class I-peptide interactions was proposed. Three hundred and forty features of HLA I proteins and peptide sequences were utilized for analysis by four candidate algorithms, screening the optimal classifier. Features derived from the optimal classifier were further selected and systematically analyzed, revealing the core regulators. The results validated the hypothesis that features of HLA I proteins and related peptides simultaneously affect the binding process, though with discrepant redundancy. Besides, the high relative ratio (16/20) of the amino acid composition features suggests the unique role of sequence signatures for the binding processes. Integrating biological, evolutionary and chemical features of both HLA I molecules and peptides, this study may provide a new perspective of the underlying mechanisms of HLA I-mediated immune reactions.
英文摘要: During the display of peptide/human leukocyte antigen (HLA)-I complex for further immune recognition, the cleaved and transported antigenic peptides have to bind to HLA-I protein and the binding affinity between peptide epitopes and HLA proteins directly influences the immune recognition ability in human beings. Key factors affecting the binding affinity during the generation, selection and presentation processes of HLA-I complex have not yet been fully discovered. In this study, a new method describing the HLA class I-peptide interactions was proposed. Three hundred and forty features of HLA I proteins and peptide sequences were utilized for analysis by four candidate algorithms, screening the optimal classifier. Features derived from the optimal classifier were further selected and systematically analyzed, revealing the core regulators. The results validated the hypothesis that features of HLA I proteins and related peptides simultaneously affect the binding process, though with discrepant redundancy. Besides, the high relative ratio (16/20) of the amino acid composition features suggests the unique role of sequence signatures for the binding processes. Integrating biological, evolutionary and chemical features of both HLA I molecules and peptides, this study may provide a new perspective of the underlying mechanisms of HLA I-mediated immune reactions.
刊物名称: SCIENTIFIC REPORTS
英文刊物名称: SCIENTIFIC REPORTS
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学科: Multidisciplinary Sciences
英文学科: Multidisciplinary Sciences
影响因子: 4.259
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论文类别: Article
英文论文类别: Article
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