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论文题目: Modeling Continuous Admixture Using Admixture-Induced Linkage Disequilibrium
英文论文题目: Modeling Continuous Admixture Using Admixture-Induced Linkage Disequilibrium
第一作者: Zhou, Y; Qiu, HX; Xu, SH
英文第一作者: Zhou, Y; Qiu, HX; Xu, SH
联系作者: Xu, SH (reprint author), Chinese Acad Sci, Key Lab Computat Biol, CAS MPG Partner Inst Computat Biol, Max Planck Independent Res Grp Populat Genom,Shan, Shanghai 200031, Peoples R China.
英文联系作者: Xu, SH (reprint author), Chinese Acad Sci, Key Lab Computat Biol, CAS MPG Partner Inst Computat Biol, Max Planck Independent Res Grp Populat Genom,Shan, Shanghai 200031, Peoples R China.
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发表年度: 2017
卷: 7
期:
页码: 1-10
摘要: Recent migrations and inter-ethnic mating of long isolated populations have resulted in genetically admixed populations. To understand the complex population admixture process, which is critical to both evolutionary and medical studies, here we used admixture induced linkage disequilibrium (LD) to infer continuous admixture events, which is common for most existing admixed populations. Unlike previous studies, we expanded the typical continuous admixture model to a more general scenario with isolation after a certain duration of continuous gene flow. Based on the new models, we developed a method, CAMer, to infer the admixture history considering continuous and complex demographic process of gene flow between populations. We evaluated the performance of CAMer by computer simulation and further applied our method to real data analysis of a few well-known admixed populations.
英文摘要: Recent migrations and inter-ethnic mating of long isolated populations have resulted in genetically admixed populations. To understand the complex population admixture process, which is critical to both evolutionary and medical studies, here we used admixture induced linkage disequilibrium (LD) to infer continuous admixture events, which is common for most existing admixed populations. Unlike previous studies, we expanded the typical continuous admixture model to a more general scenario with isolation after a certain duration of continuous gene flow. Based on the new models, we developed a method, CAMer, to infer the admixture history considering continuous and complex demographic process of gene flow between populations. We evaluated the performance of CAMer by computer simulation and further applied our method to real data analysis of a few well-known admixed populations.
刊物名称: SCIENTIFIC REPORTS
英文刊物名称: SCIENTIFIC REPORTS
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学科: Multidisciplinary Sciences
英文学科: Multidisciplinary Sciences
影响因子: 4.259
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论文类别: Article
英文论文类别: Article
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