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论文题目: Cuprous oxide nanoparticles inhibit prostate cancer by attenuating the stemness of cancer cells via inhibition of the Wnt signaling pathway
英文论文题目: Cuprous oxide nanoparticles inhibit prostate cancer by attenuating the stemness of cancer cells via inhibition of the Wnt signaling pathway
第一作者: Wang, Y; Yang, QW; Yang, Q; Zhou, T; Shi, MF; Sun, CX; Gao, XX; Cheng, YQ; Cui, XG; Sun, YH
英文第一作者: Wang, Y; Yang, QW; Yang, Q; Zhou, T; Shi, MF; Sun, CX; Gao, XX; Cheng, YQ; Cui, XG; Sun, YH
联系作者: Sun, YH (reprint author), Second Mil Med Univ, Changhai Hosp, Dept Urol, 800 Xiangyin Rd, Shanghai, Peoples R China.
英文联系作者: Sun, YH (reprint author), Second Mil Med Univ, Changhai Hosp, Dept Urol, 800 Xiangyin Rd, Shanghai, Peoples R China.
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发表年度: 2017
卷: 12
期:
页码: 2569-2579
摘要: Disordered copper metabolism plays a critical role in the development of various cancers. As a nanomedicine containing copper, cuprous oxide nanoparticles (CONPs) exert ideal antitumor pharmacological effects in vitro and in vivo. Prostate cancer is a frequently diagnosed male malignancy prone to relapse, and castration resistance is the main reason for endocrine therapy failure. However, whether CONPs have the potential to treat castration-resistant prostate cancer is still unknown. Here, using the castration-resistant PC-3 human prostate cancer cell line as a model, we report that CONPs can selectively induce apoptosis and inhibit the proliferation of cancer cells in vitro and in vivo without affecting normal prostate epithelial cells. CONPs can also attenuate the stemness of cancer cells and inhibit the Wnt signaling pathway, both of which highlight the great potential of CONPs as a new clinical castration-resistant prostate cancer therapy.
英文摘要: Disordered copper metabolism plays a critical role in the development of various cancers. As a nanomedicine containing copper, cuprous oxide nanoparticles (CONPs) exert ideal antitumor pharmacological effects in vitro and in vivo. Prostate cancer is a frequently diagnosed male malignancy prone to relapse, and castration resistance is the main reason for endocrine therapy failure. However, whether CONPs have the potential to treat castration-resistant prostate cancer is still unknown. Here, using the castration-resistant PC-3 human prostate cancer cell line as a model, we report that CONPs can selectively induce apoptosis and inhibit the proliferation of cancer cells in vitro and in vivo without affecting normal prostate epithelial cells. CONPs can also attenuate the stemness of cancer cells and inhibit the Wnt signaling pathway, both of which highlight the great potential of CONPs as a new clinical castration-resistant prostate cancer therapy.
刊物名称: INTERNATIONAL JOURNAL OF NANOMEDICINE
英文刊物名称: INTERNATIONAL JOURNAL OF NANOMEDICINE
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学科: Nanoscience & Nanotechnology; Pharmacology & Pharmacy
英文学科: Nanoscience & Nanotechnology; Pharmacology & Pharmacy
影响因子: 4.3
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论文类别: Article
英文论文类别: Article
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