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论文题目: Meta-analysis of genome-wide association studies identifies three novel loci for saturated fatty acids in East Asians
英文论文题目: Meta-analysis of genome-wide association studies identifies three novel loci for saturated fatty acids in East Asians
第一作者: Zhu, JW; Manichaikul, A; Hu, Y; Chen, YDI; Liang, S; Steffen, LM; Rich, SS; Tsai, M; Siscovick, DS; Lemaitre, RN; Li, HX; Lin, X
英文第一作者: Zhu, JW; Manichaikul, A; Hu, Y; Chen, YDI; Liang, S; Steffen, LM; Rich, SS; Tsai, M; Siscovick, DS; Lemaitre, RN; Li, HX; Lin, X
联系作者: Lin, X (reprint author), Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai, Peoples R China.
英文联系作者: Lin, X (reprint author), Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai, Peoples R China.
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发表年度: 2017
卷: 56
期: 4
页码: 1477-1484
摘要: We aimed to characterize common genetic variants that influence saturated fatty acid concentrations in East Asians. Meta-analysis of genome-wide association studies for circulating SFAs was conducted in two population-based cohorts comprising 3521 participants of Chinese ancestry. We identified two novel 14:0-associated loci at LMX1A (LIM homeobox transcription factor 1) and AMPD3 (AMP deaminase 3) (P = 5.08 x 10(-9) and P = 4.33 x 10(-8), respectively), and a novel 20:0-associated locus at CERS4 (ceramide synthase 4) (P = 1.76 x 10(-10)). We also confirmed the previously reported association of FADS1/2-rs102275 with 18:0 (P = 1.12 x 10(-5)). In addition, the A alleles of rs11042834 in AMPD3 and rs17159388 in CERS4 also exhibited evidence of associations with high-density lipoprotein cholesterol (P = 0.0162 and P = 0.0161, respectively). To our knowledge, this is the first GWAS analysis to examine SFA concentrations in East Asian populations. Our findings provide novel evidence that genetic variations of several genes from multiple pathways are associated with SFA concentrations in human body.
英文摘要: We aimed to characterize common genetic variants that influence saturated fatty acid concentrations in East Asians. Meta-analysis of genome-wide association studies for circulating SFAs was conducted in two population-based cohorts comprising 3521 participants of Chinese ancestry. We identified two novel 14:0-associated loci at LMX1A (LIM homeobox transcription factor 1) and AMPD3 (AMP deaminase 3) (P = 5.08 x 10(-9) and P = 4.33 x 10(-8), respectively), and a novel 20:0-associated locus at CERS4 (ceramide synthase 4) (P = 1.76 x 10(-10)). We also confirmed the previously reported association of FADS1/2-rs102275 with 18:0 (P = 1.12 x 10(-5)). In addition, the A alleles of rs11042834 in AMPD3 and rs17159388 in CERS4 also exhibited evidence of associations with high-density lipoprotein cholesterol (P = 0.0162 and P = 0.0161, respectively). To our knowledge, this is the first GWAS analysis to examine SFA concentrations in East Asian populations. Our findings provide novel evidence that genetic variations of several genes from multiple pathways are associated with SFA concentrations in human body.
刊物名称: EUROPEAN JOURNAL OF NUTRITION
英文刊物名称: EUROPEAN JOURNAL OF NUTRITION
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学科: Nutrition & Dietetics
英文学科: Nutrition & Dietetics
影响因子: 4.37
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论文类别: Article
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