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论文题目: Nanodiamonds Interfere with Wnt-Regulated Cell Migration and Adipocyte Differentiation in Cells and Embryonic Development In Vivo
英文论文题目: Nanodiamonds Interfere with Wnt-Regulated Cell Migration and Adipocyte Differentiation in Cells and Embryonic Development In Vivo
第一作者: Yi, HY; Li, XJ; Wang, ZY; Yin, M; Wang, LH; Aldalbahi, A; El-Sayed, NN; Wang, H; Chen, N; Chen, LN; Fan, CH; Song, HY
英文第一作者: Yi, HY; Li, XJ; Wang, ZY; Yin, M; Wang, LH; Aldalbahi, A; El-Sayed, NN; Wang, H; Chen, N; Chen, LN; Fan, CH; Song, HY
联系作者: Song, HY (reprint author), Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Food Safety Res,Inst Nutr Sci, Shanghai 200031, Peoples R China.
英文联系作者: Song, HY (reprint author), Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Food Safety Res,Inst Nutr Sci, Shanghai 200031, Peoples R China.
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发表年度: 2017
卷: 34
期: 1
页码: 1600208
摘要: Biocompatible nanoparticles hold a great promise for biomedical applications, whereas their biosafety has raised extensive concerns. Nanodiamonds (NDs) are generally regarded as inert nanocarriers and widely employed in biomedical studies; however, it is yet to explore their biological effects in more general contexts. In this study, the authors observe that intracellular NDs block signal transduction of the Wnt signaling pathway, an effect that is not caused by general cytotoxicity. The authors find that NDs attenuate activities of Wnt signaling in several types of cell lines and in Zebrafish, and interfere with Wnt signaling-controlled biological processes, including cancer cell migration, adipocyte differentiation, and embryonic development. Significantly, the authors show that intracellular NDs trigger degradation of the disheveled protein, a key component of Wnt signaling cascade, while they do not affect protein stability of other Wnt signal transducers or other signaling molecules. This work thus illustrates a novel crosstalk between nanoparticles and the Wnt signaling pathway, and expands the understanding of biological effects induced by nanoparticles. In addition, given the clinical implications of Wnt signaling in tumorigenesis and cancer metastasis, this study also provides the rationale for potential applications of NDs in cancer therapies.
英文摘要: Biocompatible nanoparticles hold a great promise for biomedical applications, whereas their biosafety has raised extensive concerns. Nanodiamonds (NDs) are generally regarded as inert nanocarriers and widely employed in biomedical studies; however, it is yet to explore their biological effects in more general contexts. In this study, the authors observe that intracellular NDs block signal transduction of the Wnt signaling pathway, an effect that is not caused by general cytotoxicity. The authors find that NDs attenuate activities of Wnt signaling in several types of cell lines and in Zebrafish, and interfere with Wnt signaling-controlled biological processes, including cancer cell migration, adipocyte differentiation, and embryonic development. Significantly, the authors show that intracellular NDs trigger degradation of the disheveled protein, a key component of Wnt signaling cascade, while they do not affect protein stability of other Wnt signal transducers or other signaling molecules. This work thus illustrates a novel crosstalk between nanoparticles and the Wnt signaling pathway, and expands the understanding of biological effects induced by nanoparticles. In addition, given the clinical implications of Wnt signaling in tumorigenesis and cancer metastasis, this study also provides the rationale for potential applications of NDs in cancer therapies.
刊物名称: PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
英文刊物名称: PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
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学科: Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
英文学科: Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
影响因子: 4.474
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论文类别: Article
英文论文类别: Article
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