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论文题目: Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians
英文论文题目: Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians
第一作者: Li, CW; Kim, YK; Dorajoo, R; Li, HX; Lee, IT; Cheng, CY; He, M; Sheu, WHH; Guo, XQ; Ganesh, SK; He, J; Lee, JY; Liu, JJ; Hu, Y; Rao, DC; Tsai, FJ; Koh, JY; Hu, H; Liang, KW; Palmas, W; Hixson, JE; Han, S; Teo, YY; Wang, YQ; Chen, J; Lu, CH; Zheng, YF; Gui, LX; Lee, WJ; Yao, J; Gu, DF; Han, BG; Sim, XL; Sun, L; Zhao, JY; Chen, CH; Kumari, N; He, YF; Taylor, KD; Raffel, LJ; Moon, S; Rotter, JI; Chen, YDI; Wu, TC; Wong, TY; Wu, JY; Lin, X; Tai, ES; Kim, BJ; Kelly, TN
英文第一作者: Li, CW; Kim, YK; Dorajoo, R; Li, HX; Lee, IT; Cheng, CY; He, M; Sheu, WHH; Guo, XQ; Ganesh, SK; He, J; Lee, JY; Liu, JJ; Hu, Y; Rao, DC; Tsai, FJ; Koh, JY; Hu, H; Liang, KW; Palmas, W; Hixson, JE; Han, S; Teo, YY; Wang, YQ; Chen, J; Lu, CH; Zheng, YF; Gui, LX; Lee, WJ; Yao, J; Gu, DF; Han, BG; Sim, XL; Sun, L; Zhao, JY; Chen, CH; Kumari, N; He, YF; Taylor, KD; Raffel, LJ; Moon, S; Rotter, JI; Chen, YDI; Wu, TC; Wong, TY; Wu, JY; Lin, X; Tai, ES; Kim, BJ; Kelly, TN
联系作者: Kelly, TN (reprint author), Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, 1440 Canal St,Suite 2000, New Orleans, LA 70112 USA.
英文联系作者: Kelly, TN (reprint author), Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, 1440 Canal St,Suite 2000, New Orleans, LA 70112 USA.
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发表年度: 2017
卷: 10
期: 2
页码: UNSP e001527
摘要: Background-Genome-wide single marker and gene-based meta-analyses of long-term average (LTA) blood pressure (BP) phenotypes may reveal novel findings for BP. Methods and Results-We conducted genome-wide analysis among 18422 East Asian participants (stage 1) followed by replication study of <= 46629 participants of European ancestry (stage 2). Significant single-nucleotide polymorphisms and genes were determined by a P<5.0x10(-8) and 2.5x10(-6), respectively, in joint analyses of stage-1 and stage-2 data. We identified 1 novel ARL3 variant, rs4919669 at 10q24.32, influencing LTA systolic BP (stage-1 P=5.03x10(-8), stage-2 P=8.64x10(-3), joint P=2.63x10(-8)) and mean arterial pressure (stage-1 P=3.59x10(-9), stage-2 P=2.35x10(-2), joint P=2.64x10(-8)). Three previously reported BP loci (WBP1L, NT5C2, and ATP2B1) were also identified for all BP phenotypes. Gene-based analysis provided the first robust evidence for association of KCNJ11 with LTA systolic BP (stage-1 P=8.55x10(-6), stage-2 P=1.62x10(-5), joint P=3.28x10(-9)) and mean arterial pressure (stage-1 P=9.19x10(-7), stage-2 P=9.69x10(-5), joint P=2.15x10(-9)) phenotypes. Fourteen genes (TMEM180, ACTR1A, SUFU, ARL3, SFXN2, WBP1L, CYP17A1, C10orf32, C10orf32-ASMT, AS3MT, CNNM2, and NT5C2 at 10q24.32; ATP2B1 at 12q21.33; and NCR3LG1 at 11p15.1) implicated by previous genome-wide association study meta-analyses were also identified. Among the loci identified by the previous genome-wide association study meta-analysis of LTA BP, we transethnically replicated associations of the KCNK3 marker rs1275988 at 2p23.3 with LTA systolic BP and mean arterial pressure phenotypes (P=1.27x10(-4) and 3.30x10(-4), respectively). Conclusions-We identified 1 novel variant and 1 novel gene and present the first direct evidence of relevance of the KCNK3 locus for LTA BP among East Asians.
英文摘要: Background-Genome-wide single marker and gene-based meta-analyses of long-term average (LTA) blood pressure (BP) phenotypes may reveal novel findings for BP. Methods and Results-We conducted genome-wide analysis among 18422 East Asian participants (stage 1) followed by replication study of <= 46629 participants of European ancestry (stage 2). Significant single-nucleotide polymorphisms and genes were determined by a P<5.0x10(-8) and 2.5x10(-6), respectively, in joint analyses of stage-1 and stage-2 data. We identified 1 novel ARL3 variant, rs4919669 at 10q24.32, influencing LTA systolic BP (stage-1 P=5.03x10(-8), stage-2 P=8.64x10(-3), joint P=2.63x10(-8)) and mean arterial pressure (stage-1 P=3.59x10(-9), stage-2 P=2.35x10(-2), joint P=2.64x10(-8)). Three previously reported BP loci (WBP1L, NT5C2, and ATP2B1) were also identified for all BP phenotypes. Gene-based analysis provided the first robust evidence for association of KCNJ11 with LTA systolic BP (stage-1 P=8.55x10(-6), stage-2 P=1.62x10(-5), joint P=3.28x10(-9)) and mean arterial pressure (stage-1 P=9.19x10(-7), stage-2 P=9.69x10(-5), joint P=2.15x10(-9)) phenotypes. Fourteen genes (TMEM180, ACTR1A, SUFU, ARL3, SFXN2, WBP1L, CYP17A1, C10orf32, C10orf32-ASMT, AS3MT, CNNM2, and NT5C2 at 10q24.32; ATP2B1 at 12q21.33; and NCR3LG1 at 11p15.1) implicated by previous genome-wide association study meta-analyses were also identified. Among the loci identified by the previous genome-wide association study meta-analysis of LTA BP, we transethnically replicated associations of the KCNK3 marker rs1275988 at 2p23.3 with LTA systolic BP and mean arterial pressure phenotypes (P=1.27x10(-4) and 3.30x10(-4), respectively). Conclusions-We identified 1 novel variant and 1 novel gene and present the first direct evidence of relevance of the KCNK3 locus for LTA BP among East Asians.
刊物名称: CIRCULATION-CARDIOVASCULAR GENETICS
英文刊物名称: CIRCULATION-CARDIOVASCULAR GENETICS
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学科: Cardiac & Cardiovascular Systems; Genetics & Heredity
英文学科: Cardiac & Cardiovascular Systems; Genetics & Heredity
影响因子: 4.743
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论文类别: Article
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