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论文题目: Aging-associated oxidative stress inhibits liver progenitor cell activation in mice
英文论文题目: Aging-associated oxidative stress inhibits liver progenitor cell activation in mice
第一作者: Cheng, YJ; Wang, X; Wang, B; Zhou, H; Dang, SP; Shi, YF; Hao, L; Luo, QQ; Jin, M; Zhou, QJ; Zhang, YY
英文第一作者: Cheng, YJ; Wang, X; Wang, B; Zhou, H; Dang, SP; Shi, YF; Hao, L; Luo, QQ; Jin, M; Zhou, QJ; Zhang, YY
联系作者: Zhang, YY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai, Peoples R China.
英文联系作者: Zhang, YY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai, Peoples R China.
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发表年度: 2017
卷: 9
期: 5
页码: 1359-1374
摘要: Recent studies have discovered aging-associated changes of adult stem cells in various tissues and organs, which potentially contribute to the organismal aging. However, aging-associated changes of liver progenitor cells (LPCs) remain elusive. Employing young (2-month-old) and old (24-month-old) mice, we found diverse novel alterations in LPC activation during aging. LPCs in young mice could be activated and proliferate upon liver injury, whereas the counterparts in old mice failed to respond and proliferate, leading to the impaired liver regeneration. Surprisingly, isolated LPCs from young and old mice did not exhibit significant difference in their clonogenic and proliferative capacity. Later, we uncovered that the decreased activation and proliferation of LPCs were due to excessive reactive oxygen species produced by neutrophils infiltrated into niche, which was resulted from chemokine production from activated hepatic stellate cells during aging. This study demonstrates aging-associated changes in LPC activation and reveals critical roles for the stem cell niche, including neutrophils and hepatic stellate cells, in the negative regulation of LPCs during aging.
英文摘要: Recent studies have discovered aging-associated changes of adult stem cells in various tissues and organs, which potentially contribute to the organismal aging. However, aging-associated changes of liver progenitor cells (LPCs) remain elusive. Employing young (2-month-old) and old (24-month-old) mice, we found diverse novel alterations in LPC activation during aging. LPCs in young mice could be activated and proliferate upon liver injury, whereas the counterparts in old mice failed to respond and proliferate, leading to the impaired liver regeneration. Surprisingly, isolated LPCs from young and old mice did not exhibit significant difference in their clonogenic and proliferative capacity. Later, we uncovered that the decreased activation and proliferation of LPCs were due to excessive reactive oxygen species produced by neutrophils infiltrated into niche, which was resulted from chemokine production from activated hepatic stellate cells during aging. This study demonstrates aging-associated changes in LPC activation and reveals critical roles for the stem cell niche, including neutrophils and hepatic stellate cells, in the negative regulation of LPCs during aging.
刊物名称: AGING-US
英文刊物名称: AGING-US
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学科: Cell Biology; Geriatrics & Gerontology
英文学科: Cell Biology; Geriatrics & Gerontology
影响因子: 4.867
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论文类别: Article
英文论文类别: Article
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