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论文题目: Changes in Lipidome Composition during Brain Development in Humans, Chimpanzees, and Macaque Monkeys
英文论文题目: Changes in Lipidome Composition during Brain Development in Humans, Chimpanzees, and Macaque Monkeys
第一作者: Li, Q; Bozek, K; Xu, C; Guo, YA; Sun, J; Paabo, S; Sherwood, CC; Hof, PR; Ely, JJ; Li, Y; Willmitzer, L; Giavalisco, P; Khaitovich, P
英文第一作者: Li, Q; Bozek, K; Xu, C; Guo, YA; Sun, J; Paabo, S; Sherwood, CC; Hof, PR; Ely, JJ; Li, Y; Willmitzer, L; Giavalisco, P; Khaitovich, P
联系作者: Khaitovich, P (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Key Lab Computat Biol, CAS MPG Partner Inst Computat Biol, Shanghai, Peoples R China.
英文联系作者: Khaitovich, P (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Key Lab Computat Biol, CAS MPG Partner Inst Computat Biol, Shanghai, Peoples R China.
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发表年度: 2017
卷: 34
期: 5
页码: 1155-1166
摘要: Lipids are essential components of the brain. Here, we conducted a comprehensive mass spectrometry-based analysis of lipidome composition in the prefrontal cortex of 40 humans, 40 chimpanzees, and 40 rhesus monkeys over postnatal development and adulthood. Of the 11,772 quantified lipid peaks, 7,589 change significantly along the lifespan. More than 60% of these changes occur prior to adulthood, with less than a quarter associated with myelination progression. Evolutionarily, 36% of the age-dependent lipids exhibit concentration profiles distinct to one of the three species; 488 (18%) of them were unique to humans. In both humans and chimpanzees, the greatest extent of species-specific differences occurs in early development. Human-specific lipidome differences, however, persist over most of the lifespan and reach their peak from 20 to 35 years of age, when compared with chimpanzee-specific ones.
英文摘要: Lipids are essential components of the brain. Here, we conducted a comprehensive mass spectrometry-based analysis of lipidome composition in the prefrontal cortex of 40 humans, 40 chimpanzees, and 40 rhesus monkeys over postnatal development and adulthood. Of the 11,772 quantified lipid peaks, 7,589 change significantly along the lifespan. More than 60% of these changes occur prior to adulthood, with less than a quarter associated with myelination progression. Evolutionarily, 36% of the age-dependent lipids exhibit concentration profiles distinct to one of the three species; 488 (18%) of them were unique to humans. In both humans and chimpanzees, the greatest extent of species-specific differences occurs in early development. Human-specific lipidome differences, however, persist over most of the lifespan and reach their peak from 20 to 35 years of age, when compared with chimpanzee-specific ones.
刊物名称: MOLECULAR BIOLOGY AND EVOLUTION
英文刊物名称: MOLECULAR BIOLOGY AND EVOLUTION
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学科: Biochemistry & Molecular Biology; Evolutionary Biology; Genetics & Heredity
英文学科: Biochemistry & Molecular Biology; Evolutionary Biology; Genetics & Heredity
影响因子: 6.202
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论文类别: Article
英文论文类别: Article
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