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论文题目: LIN-28 balances longevity and germline stem cell number in Caenorhabditis elegans through let-7/AKT/DAF-16 axis
英文论文题目: LIN-28 balances longevity and germline stem cell number in Caenorhabditis elegans through let-7/AKT/DAF-16 axis
第一作者: Wang, D; Hou, L; Nakamura, S; Su, M; Li, F; Chen, WY; Yan, YZ; Green, CD; Chen, D; Zhang, H; Antebi, A; Han, JDJ
英文第一作者: Wang, D; Hou, L; Nakamura, S; Su, M; Li, F; Chen, WY; Yan, YZ; Green, CD; Chen, D; Zhang, H; Antebi, A; Han, JDJ
联系作者: Han, JDJ (reprint author),Shanghai Inst Bio, Key Lab Computat Biol,Collaborat Innovat Ctr Gene, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.
英文联系作者: Han, JDJ (reprint author),Shanghai Inst Bio, Key Lab Computat Biol,Collaborat Innovat Ctr Gene, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.
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发表年度: 2017
卷: 16
期: 1
页码: 113-124
摘要: The RNA-binding protein LIN-28 was first found to control developmental timing in Caenorhabditis elegans. Later, it was found to play important roles in pluripotency, metabolism, and cancer in mammals. Here we report that a low dosage of lin-28 enhanced stress tolerance and longevity, and reduced germline stem/progenitor cell number in C. elegans. The germline LIN-28-regulated microRNA let-7 was required for these effects by targeting akt-1/2 and decreasing their protein levels. AKT-1/2 and the downstream DAF-16 transcription factor were both required for the lifespan and germline stem cell effects of lin-28. The pathway also mediated dietary restriction induced lifespan extension and reduction in germline stem cell number. Thus, the LIN-28/let-7/AKT/DAF-16 axis we delineated here is a program that plays an important role in balancing reproduction and somatic maintenance and their response to the environmental energy level-a central dogma of the 'evolutionary optimization' of resource allocation that modulates aging.
英文摘要: The RNA-binding protein LIN-28 was first found to control developmental timing in Caenorhabditis elegans. Later, it was found to play important roles in pluripotency, metabolism, and cancer in mammals. Here we report that a low dosage of lin-28 enhanced stress tolerance and longevity, and reduced germline stem/progenitor cell number in C. elegans. The germline LIN-28-regulated microRNA let-7 was required for these effects by targeting akt-1/2 and decreasing their protein levels. AKT-1/2 and the downstream DAF-16 transcription factor were both required for the lifespan and germline stem cell effects of lin-28. The pathway also mediated dietary restriction induced lifespan extension and reduction in germline stem cell number. Thus, the LIN-28/let-7/AKT/DAF-16 axis we delineated here is a program that plays an important role in balancing reproduction and somatic maintenance and their response to the environmental energy level-a central dogma of the 'evolutionary optimization' of resource allocation that modulates aging.
刊物名称: AGING CELL
英文刊物名称: AGING CELL
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学科: Cell Biology; Geriatrics & Gerontology
英文学科: Cell Biology; Geriatrics & Gerontology
影响因子: 6.714
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论文类别: Article
英文论文类别: Article
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