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论文题目: Inactivation of STAT3 Signaling Impairs Hair Cell Differentiation in the Developing Mouse Cochlea
英文论文题目: Inactivation of STAT3 Signaling Impairs Hair Cell Differentiation in the Developing Mouse Cochlea
第一作者: Chen, QQ; Quan, YZ; Wang, NT; Xie, CY; Ji, ZZ; He, H; Chai, RJ; Li, HW; Yin, SK; Chin, YE; Wei, XB; Gao, WQ
英文第一作者: Chen, QQ; Quan, YZ; Wang, NT; Xie, CY; Ji, ZZ; He, H; Chai, RJ; Li, HW; Yin, SK; Chin, YE; Wei, XB; Gao, WQ
联系作者: Wei, XB; Gao, WQ (reprint author), Shanghai Jiao Tong Univ, Renji MedX Stem Cell Res Ctr, State Key Lab Oncogenes & Related Genes, Ren Ji Hosp,Sch Biomed Engn, Shanghai 200030, Peoples R China.
英文联系作者: Wei, XB; Gao, WQ (reprint author), Shanghai Jiao Tong Univ, Renji MedX Stem Cell Res Ctr, State Key Lab Oncogenes & Related Genes, Ren Ji Hosp,Sch Biomed Engn, Shanghai 200030, Peoples R China.
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发表年度: 2017
卷: 9
期: 1
页码: 231-246
摘要: Although STAT3 signaling is demonstrated to regulate sensory cell differentiation and regeneration in the zebrafish, its exact role is still unclear in mammalian cochleae. Here, we report that STAT3 and its activated form are specifically expressed in hair cells during mouse cochlear development. Importantly, conditional cochlear deletion of Stat3 leads to an inhibition on hair cell differentiation in mice in vivo and in vitro. By cell fate analysis, inactivation of STAT3 signaling shifts the cell division modes from asymmetric to symmetric divisions from supporting cells. Moreover, inhibition of Notch signaling stimulates STAT3 phosphorylation, and inactivation of STAT3 signaling attenuates production of supernumerary hair cells induced by a Notch pathway inhibitor. Our findings highlight an important role of the STAT3 signaling during mouse cochlear hair cell differentiation and may have clinical implications for the recovery of hair cell loss-induced hearing impairment.
英文摘要: Although STAT3 signaling is demonstrated to regulate sensory cell differentiation and regeneration in the zebrafish, its exact role is still unclear in mammalian cochleae. Here, we report that STAT3 and its activated form are specifically expressed in hair cells during mouse cochlear development. Importantly, conditional cochlear deletion of Stat3 leads to an inhibition on hair cell differentiation in mice in vivo and in vitro. By cell fate analysis, inactivation of STAT3 signaling shifts the cell division modes from asymmetric to symmetric divisions from supporting cells. Moreover, inhibition of Notch signaling stimulates STAT3 phosphorylation, and inactivation of STAT3 signaling attenuates production of supernumerary hair cells induced by a Notch pathway inhibitor. Our findings highlight an important role of the STAT3 signaling during mouse cochlear hair cell differentiation and may have clinical implications for the recovery of hair cell loss-induced hearing impairment.
刊物名称: STEM CELL REPORTS
英文刊物名称: STEM CELL REPORTS
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学科: Cell & Tissue Engineering; Cell Biology
英文学科: Cell & Tissue Engineering; Cell Biology
影响因子: 7.338
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论文类别: Article
英文论文类别: Article
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