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论文题目: Bipotent progenitors as embryonic origin of retinal stem cells
英文论文题目: Bipotent progenitors as embryonic origin of retinal stem cells
第一作者: Tang, X; Gao, JN; Jia, XL; Zhao, WC; Zhang, YJ; Pan, WJ; He, J
英文第一作者: Tang, X; Gao, JN; Jia, XL; Zhao, WC; Zhang, YJ; Pan, WJ; He, J
联系作者: He, J (reprint author), Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai Inst Biol Sci, State Key Lab Neurosci,Inst Neurosci, Shanghai 200031, Peoples R China.
英文联系作者: He, J (reprint author), Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai Inst Biol Sci, State Key Lab Neurosci,Inst Neurosci, Shanghai 200031, Peoples R China.
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发表年度: 2017
卷: 216
期: 6
页码: 1833-1847
摘要: In lower vertebrates, retinal stem cells (RSCs) capable of producing all retinal cell types are a resource for retinal tissue growth throughout life. However, the embryonic origin of RSCs remains largely elusive. Using a Zebrabow-based clonal analysis, we characterized the RSC niche in the ciliary marginal zone of zebrafish retina and illustrate that blood vessels associated with RSCs are required for the maintenance of actively proliferating RSCs. Full lineage analysis of RSC progenitors reveals lineage patterns of RSC production. Moreover, in vivo lineage analysis demonstrates that these RSC progenitors are the direct descendants of a set of bipotent progenitors in the medial epithelial layer of developing optic vesicles, suggesting the involvement of the mixed-lineage states in the RSC lineage specification.
英文摘要: In lower vertebrates, retinal stem cells (RSCs) capable of producing all retinal cell types are a resource for retinal tissue growth throughout life. However, the embryonic origin of RSCs remains largely elusive. Using a Zebrabow-based clonal analysis, we characterized the RSC niche in the ciliary marginal zone of zebrafish retina and illustrate that blood vessels associated with RSCs are required for the maintenance of actively proliferating RSCs. Full lineage analysis of RSC progenitors reveals lineage patterns of RSC production. Moreover, in vivo lineage analysis demonstrates that these RSC progenitors are the direct descendants of a set of bipotent progenitors in the medial epithelial layer of developing optic vesicles, suggesting the involvement of the mixed-lineage states in the RSC lineage specification.
刊物名称: JOURNAL OF CELL BIOLOGY
英文刊物名称: JOURNAL OF CELL BIOLOGY
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学科: Cell Biology
英文学科: Cell Biology
影响因子: 7.955
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论文类别: Article
英文论文类别: Article
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