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论文题目: Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration
英文论文题目: Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration
第一作者: Song, J; Zhang, XL; Buscher, K; Wang, Y; Wang, HY; Di Russo, J; Li, LX; Lutke-Enking, S; Zarbock, A; Stadtmann, A; Striewski, P; Wirth, B; Kuzmanov, I; Wiendl, H; Schulte, D; Vestweber, D; Sorokin, L
英文第一作者: Song, J; Zhang, XL; Buscher, K; Wang, Y; Wang, HY; Di Russo, J; Li, LX; Lutke-Enking, S; Zarbock, A; Stadtmann, A; Striewski, P; Wirth, B; Kuzmanov, I; Wiendl, H; Schulte, D; Vestweber, D; Sorokin, L
联系作者: Sorokin, L (reprint author), Univ Munster, Inst Physiol Chem & Pathobiochem, D-48149 Munster, Germany.
英文联系作者: Sorokin, L (reprint author), Univ Munster, Inst Physiol Chem & Pathobiochem, D-48149 Munster, Germany.
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发表年度: 2017
卷: 18
期: 5
页码: 1256-1269
摘要: Endothelial basement membranes constitute barriers to extravasating leukocytes during inflammation, a process where laminin isoforms define sites of leukocyte exit; however, how this occurs is poorly understood. In addition to a direct effect on leukocyte transmigration, we show that laminin 511 affects endothelial barrier function by stabilizing VE-cadherin at junctions and downregulating expression of CD99L2, correlating with reduced neutrophil extravasation. Binding of endothelial cells to laminin 511, but not laminin 411 or non-endothelial laminin 111, enhanced transendothelial cell electrical resistance (TEER) and inhibited neutrophil transmigration. Data suggest that endothelial adhesion to laminin 511 via beta 1 and beta 3 integrins mediates RhoA-induced VE-cadherin localization to cell-cell borders, and while CD99L2 downregulation requires integrin beta 1, it is RhoA-independent. Our data demonstrate that molecular information provided by basement membrane laminin 511 affects leukocyte extravasation both directly and indirectly by modulating endothelial barrier properties.
英文摘要: Endothelial basement membranes constitute barriers to extravasating leukocytes during inflammation, a process where laminin isoforms define sites of leukocyte exit; however, how this occurs is poorly understood. In addition to a direct effect on leukocyte transmigration, we show that laminin 511 affects endothelial barrier function by stabilizing VE-cadherin at junctions and downregulating expression of CD99L2, correlating with reduced neutrophil extravasation. Binding of endothelial cells to laminin 511, but not laminin 411 or non-endothelial laminin 111, enhanced transendothelial cell electrical resistance (TEER) and inhibited neutrophil transmigration. Data suggest that endothelial adhesion to laminin 511 via beta 1 and beta 3 integrins mediates RhoA-induced VE-cadherin localization to cell-cell borders, and while CD99L2 downregulation requires integrin beta 1, it is RhoA-independent. Our data demonstrate that molecular information provided by basement membrane laminin 511 affects leukocyte extravasation both directly and indirectly by modulating endothelial barrier properties.
刊物名称: CELL REPORTS
英文刊物名称: CELL REPORTS
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学科: Cell Biology
英文学科: Cell Biology
影响因子: 8.282
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论文类别: Article
英文论文类别: Article
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