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论文题目: Niacin ameliorates ulcerative colitis via prostaglandin D-2-mediated D prostanoid receptor 1 activation
英文论文题目: Niacin ameliorates ulcerative colitis via prostaglandin D-2-mediated D prostanoid receptor 1 activation
第一作者: Li, JJ; Kong, DP; Wang, Q; Wu, W; Tang, YP; Bai, TT; Guo, L; Wei, LM; Zhang, QQ; Yu, Y; Qian, YT; Zuo, SK; Liu, GZ; Liu, Q; Wu, S; Zang, Y; Zhu, Q; Jia, DL; Wang, YY; Yao, WY; Ji, Y; Yin, HY; Nakamura, M; Lazarus, M; Breyer, RM; Wang, LF; Yu, Y
英文第一作者: Li, JJ; Kong, DP; Wang, Q; Wu, W; Tang, YP; Bai, TT; Guo, L; Wei, LM; Zhang, QQ; Yu, Y; Qian, YT; Zuo, SK; Liu, GZ; Liu, Q; Wu, S; Zang, Y; Zhu, Q; Jia, DL; Wang, YY; Yao, WY; Ji, Y; Yin, HY; Nakamura, M; Lazarus, M; Breyer, RM; Wang, LF; Yu, Y
联系作者: Yu, Y (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Food Safety Res, Shanghai, Peoples R China.
英文联系作者: Yu, Y (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Food Safety Res, Shanghai, Peoples R China.
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发表年度: 2017
卷: 9
期: 5
页码: 571-588
摘要: Niacin, as an antidyslipidemic drug, elicits a strong flushing response by release of prostaglandin (PG) D-2. However, whether niacin is beneficial for inflammatory bowel disease (IBD) remains unclear. Here, we observed niacin administration-enhanced PGD(2) production in colon tissues in dextran sulfate sodium (DSS)-challenged mice, and protected mice against DSS or 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in D prostanoid receptor 1 (DP1)-dependent manner. Specific ablation of DP1 receptor in vascular endothelial cells, colonic epithelium, and myeloid cells augmented DSS/TNBS-induced colitis in mice through increasing vascular permeability, promoting apoptosis of epithelial cells, and stimulating pro-inflammatory cytokine secretion of macrophages, respectively. Niacin treatment improved vascular permeability, reduced apoptotic epithelial cells, promoted epithelial cell update, and suppressed pro-inflammatory gene expression of macrophages. Moreover, treatment with niacin-containing retention enema effectively promoted UC clinical remission and mucosal healing in patients with moderately active disease. Therefore, niacin displayed multiple beneficial effects on DSS/TNBS-induced colitis in mice by activation of PGD(2)/DP1 axis. The potential efficacy of niacin in management of IBD warrants further investigation.
英文摘要: Niacin, as an antidyslipidemic drug, elicits a strong flushing response by release of prostaglandin (PG) D-2. However, whether niacin is beneficial for inflammatory bowel disease (IBD) remains unclear. Here, we observed niacin administration-enhanced PGD(2) production in colon tissues in dextran sulfate sodium (DSS)-challenged mice, and protected mice against DSS or 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in D prostanoid receptor 1 (DP1)-dependent manner. Specific ablation of DP1 receptor in vascular endothelial cells, colonic epithelium, and myeloid cells augmented DSS/TNBS-induced colitis in mice through increasing vascular permeability, promoting apoptosis of epithelial cells, and stimulating pro-inflammatory cytokine secretion of macrophages, respectively. Niacin treatment improved vascular permeability, reduced apoptotic epithelial cells, promoted epithelial cell update, and suppressed pro-inflammatory gene expression of macrophages. Moreover, treatment with niacin-containing retention enema effectively promoted UC clinical remission and mucosal healing in patients with moderately active disease. Therefore, niacin displayed multiple beneficial effects on DSS/TNBS-induced colitis in mice by activation of PGD(2)/DP1 axis. The potential efficacy of niacin in management of IBD warrants further investigation.
刊物名称: EMBO MOLECULAR MEDICINE
英文刊物名称: EMBO MOLECULAR MEDICINE
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学科: Medicine, Research & Experimental
英文学科: Medicine, Research & Experimental
影响因子: 9.249
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论文类别: Article
英文论文类别: Article
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