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论文题目: The Diversity of Long Noncoding RNAs and Their Generation
英文论文题目: The Diversity of Long Noncoding RNAs and Their Generation
第一作者: Wu, H; Yang, L; Chen, LL
英文第一作者: Wu, H; Yang, L; Chen, LL
联系作者: Yang, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Computat Biol, CAS MPG Partner Inst Computat Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China.
英文联系作者: Yang, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Computat Biol, CAS MPG Partner Inst Computat Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China.
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发表年度: 2017
卷: 33
期: 8
页码: 540-552
摘要: Long noncoding RNAs (lncRNAs) are emerging as potential key regulators in gene expression networks and exhibit a surprising range of shapes and sizes. Several distinct classes of lncRNAs are transcribed from different DNA elements, including promoters, enhancers, and intergenic regions in eukaryotic genomes. Additionally, others are derived from long primary transcripts with noncanonical RNA processing pathways, generating new RNA species with unexpected formats. These lncRNAs can be processed by several mechanisms, including ribonuclease P (RNase P) cleavage to generate mature 30 ends, capping by small nucleolar RNA (snoRNA)-protein (snoRNP) complexes at their ends, or the formation of circular structures. Here we review current knowledge on lncRNAs and highlight the most recent discoveries of the underlying mechanisms related to their formation.
英文摘要: Long noncoding RNAs (lncRNAs) are emerging as potential key regulators in gene expression networks and exhibit a surprising range of shapes and sizes. Several distinct classes of lncRNAs are transcribed from different DNA elements, including promoters, enhancers, and intergenic regions in eukaryotic genomes. Additionally, others are derived from long primary transcripts with noncanonical RNA processing pathways, generating new RNA species with unexpected formats. These lncRNAs can be processed by several mechanisms, including ribonuclease P (RNase P) cleavage to generate mature 30 ends, capping by small nucleolar RNA (snoRNA)-protein (snoRNP) complexes at their ends, or the formation of circular structures. Here we review current knowledge on lncRNAs and highlight the most recent discoveries of the underlying mechanisms related to their formation.
刊物名称: TRENDS IN GENETICS
英文刊物名称: TRENDS IN GENETICS
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学科: Genetics & Heredity
英文学科: Genetics & Heredity
影响因子: 10.844
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论文类别: Article
英文论文类别: Article
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2014 中国科学院上海生命科学研究院 版权所有