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论文题目: Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20
英文论文题目: Regulation of hepatic lipogenesis by the zinc finger protein Zbtb20
第一作者: Liu, G; Zhou, LT; Zhang, H; Chen, R; Zhang, Y; Li, L; Lu, JY; Jiang, H; Liu, D; Qi, SS; Jiang, YM; Yin, K; Xie, ZF; Shi, YG; Liu, Y; Cao, XT; Chen, YX; Zou, DJ; Zhang, WPJ
英文第一作者: Liu, G; Zhou, LT; Zhang, H; Chen, R; Zhang, Y; Li, L; Lu, JY; Jiang, H; Liu, D; Qi, SS; Jiang, YM; Yin, K; Xie, ZF; Shi, YG; Liu, Y; Cao, XT; Chen, YX; Zou, DJ; Zhang, WPJ
联系作者: Zhang, WPJ (reprint author), Second Mil Med Univ, Dept Pathophysiol, Shanghai 200433, Peoples R China.
英文联系作者: Zhang, WPJ (reprint author), Second Mil Med Univ, Dept Pathophysiol, Shanghai 200433, Peoples R China.
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发表年度: 2017
卷: 8
期:
页码: 14824
摘要: Hepatic de novo lipogenesis (DNL) converts carbohydrates into triglycerides and is known to influence systemic lipid homoeostasis. Here, we demonstrate that the zinc finger protein Zbtb20 is required for DNL. Mice lacking Zbtb20 in the liver exhibit hypolipidemia and reduced levels of liver triglycerides, along with impaired hepatic lipogenesis. The expression of genes involved in glycolysis and DNL, including that of two ChREBP isoforms, is decreased in livers of knockout mice. Zbtb20 binds to and enhances the activity of the ChREBP-alpha promoter, suggesting that altered metabolic gene expression is mainly driven by ChREBP. In addition, ChREBP-beta overexpression largely restores hepatic expression of genes involved in glucose and lipid metabolism, and increases plasma and liver triglyceride levels in knockout mice. Finally, we show that Zbtb20 ablation protects from diet-induced liver steatosis and improves hepatic insulin resistance. We suggest ZBTB20 is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease.
英文摘要: Hepatic de novo lipogenesis (DNL) converts carbohydrates into triglycerides and is known to influence systemic lipid homoeostasis. Here, we demonstrate that the zinc finger protein Zbtb20 is required for DNL. Mice lacking Zbtb20 in the liver exhibit hypolipidemia and reduced levels of liver triglycerides, along with impaired hepatic lipogenesis. The expression of genes involved in glycolysis and DNL, including that of two ChREBP isoforms, is decreased in livers of knockout mice. Zbtb20 binds to and enhances the activity of the ChREBP-alpha promoter, suggesting that altered metabolic gene expression is mainly driven by ChREBP. In addition, ChREBP-beta overexpression largely restores hepatic expression of genes involved in glucose and lipid metabolism, and increases plasma and liver triglyceride levels in knockout mice. Finally, we show that Zbtb20 ablation protects from diet-induced liver steatosis and improves hepatic insulin resistance. We suggest ZBTB20 is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease.
刊物名称: NATURE COMMUNICATIONS
英文刊物名称: NATURE COMMUNICATIONS
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学科: Multidisciplinary Sciences
英文学科: Multidisciplinary Sciences
影响因子: 12.124
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论文类别: Article
英文论文类别: Article
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