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论文题目: Antigen-specific CD8(+) T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin
英文论文题目: Antigen-specific CD8(+) T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin
第一作者: Yao, YK; Chen, SY; Cao, MT; Fan, X; Yang, T; Huang, Y; Song, XY; Li, YQ; Ye, LL; Shen, N; Shi, YF; Li, XX; Wang, F; Qian, YC
英文第一作者: Yao, YK; Chen, SY; Cao, MT; Fan, X; Yang, T; Huang, Y; Song, XY; Li, YQ; Ye, LL; Shen, N; Shi, YF; Li, XX; Wang, F; Qian, YC
联系作者: Qian, YC (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, CAS Ctr Excellence Mol Cell Sci,Key Lab Stem Cell, Shanghai 200031, Peoples R China.
英文联系作者: Qian, YC (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, CAS Ctr Excellence Mol Cell Sci,Key Lab Stem Cell, Shanghai 200031, Peoples R China.
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发表年度: 2017
卷: 8
期:
页码: 15402
摘要: The connection between innate and adaptive immunity is best exemplified by antigen presentation. Although antigen-presenting cells (APCs) are required for antigen receptor-mediated T-cell activation, how T-cells feedback to APCs to sustain an antigen-specific immune response is not completely clear. Here we show that CD8(+) T-cell (also called cytotoxic T lymphocytes, CTL) feedback activates the NLRP3 inflammasome in APCs in an antigen-dependent manner to promote IL-1 beta maturation. Perforin from antigen-specific CTLs is required for NLRP3 inflammasome activation in APCs. Furthermore, such activation of NLRP3 inflammasome contributes to the induction of antigen-specific antitumour immunity and pathogenesis of graft-versus-host diseases. Our study reveals a positive feedback loop between antigen-specific CTLs and APC to amplify adaptive immunity.
英文摘要: The connection between innate and adaptive immunity is best exemplified by antigen presentation. Although antigen-presenting cells (APCs) are required for antigen receptor-mediated T-cell activation, how T-cells feedback to APCs to sustain an antigen-specific immune response is not completely clear. Here we show that CD8(+) T-cell (also called cytotoxic T lymphocytes, CTL) feedback activates the NLRP3 inflammasome in APCs in an antigen-dependent manner to promote IL-1 beta maturation. Perforin from antigen-specific CTLs is required for NLRP3 inflammasome activation in APCs. Furthermore, such activation of NLRP3 inflammasome contributes to the induction of antigen-specific antitumour immunity and pathogenesis of graft-versus-host diseases. Our study reveals a positive feedback loop between antigen-specific CTLs and APC to amplify adaptive immunity.
刊物名称: NATURE COMMUNICATIONS
英文刊物名称: NATURE COMMUNICATIONS
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学科: Multidisciplinary Sciences
英文学科: Multidisciplinary Sciences
影响因子: 12.124
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论文类别: Article
英文论文类别: Article
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