论文库首页  论文库
 
论文编号:
论文题目: Identification of a hybrid myocardial zone in the mammalian heart after birth
英文论文题目: Identification of a hybrid myocardial zone in the mammalian heart after birth
第一作者: Tian, XY; Li, Y; He, LJ; Zhang, H; Huang, XZ; Liu, QZ; Pu, WJ; Zhang, LB; Li, Y; Zhao, H; Wang, ZF; Zhu, JH; Nie, Y; Hu, SS; Sedmera, D; Zhong, TP; Yu, Y; Zhang, L; Yan, Y; Qiao, ZY; Wang, QD; Wu, SM; Pu, WT; Anderson, RH; Zhou, B
英文第一作者: Tian, XY; Li, Y; He, LJ; Zhang, H; Huang, XZ; Liu, QZ; Pu, WJ; Zhang, LB; Li, Y; Zhao, H; Wang, ZF; Zhu, JH; Nie, Y; Hu, SS; Sedmera, D; Zhong, TP; Yu, Y; Zhang, L; Yan, Y; Qiao, ZY; Wang, QD; Wu, SM; Pu, WT; Anderson, RH; Zhou, B
联系作者: Zhou, B (reprint author), Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China.
英文联系作者: Zhou, B (reprint author), Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China.
外单位作者单位:
英文外单位作者单位:
发表年度: 2017
卷: 8
期:
页码: 87
摘要: Noncompaction cardiomyopathy is characterized by the presence of extensive trabeculations, which could lead to heart failure and malignant arrhythmias. How trabeculations resolve to form compact myocardium is poorly understood. Elucidation of this process is critical to understanding the pathophysiology of noncompaction disease. Here we use genetic lineage tracing to mark the Nppa(+) or Hey(2+) cardiomyocytes as trabecular and compact components of the ventricular wall. We find that Nppa(+) and Hey(2+) cardiomyocytes, respectively, from the endocardial and epicardial zones of the ventricular wall postnatally. Interposed between these two postnatal layers is a hybrid zone, which is composed of cells derived from both the Nppa(+) and Hey(2+) populations. Inhibition of the fetal Hey(2+) cell contribution to the hybrid zone results in persistence of excessive trabeculations in postnatal heart. Our findings indicate that the expansion of Hey(2+) fetal compact component, and its contribution to the hybrid myocardial zone, are essential for normal formation of the ventricular walls.
英文摘要: Noncompaction cardiomyopathy is characterized by the presence of extensive trabeculations, which could lead to heart failure and malignant arrhythmias. How trabeculations resolve to form compact myocardium is poorly understood. Elucidation of this process is critical to understanding the pathophysiology of noncompaction disease. Here we use genetic lineage tracing to mark the Nppa(+) or Hey(2+) cardiomyocytes as trabecular and compact components of the ventricular wall. We find that Nppa(+) and Hey(2+) cardiomyocytes, respectively, from the endocardial and epicardial zones of the ventricular wall postnatally. Interposed between these two postnatal layers is a hybrid zone, which is composed of cells derived from both the Nppa(+) and Hey(2+) populations. Inhibition of the fetal Hey(2+) cell contribution to the hybrid zone results in persistence of excessive trabeculations in postnatal heart. Our findings indicate that the expansion of Hey(2+) fetal compact component, and its contribution to the hybrid myocardial zone, are essential for normal formation of the ventricular walls.
刊物名称: NATURE COMMUNICATIONS
英文刊物名称: NATURE COMMUNICATIONS
论文全文:
英文论文全文:
全文链接:
其它备注:
英文其它备注:
学科: Multidisciplinary Sciences
英文学科: Multidisciplinary Sciences
影响因子: 12.124
第一作者所在部门:
英文第一作者所在部门:
论文出处:
英文论文出处:
论文类别: Article
英文论文类别: Article
参与作者:
英文参与作者:
 
2014 中国科学院上海生命科学研究院 版权所有