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论文题目: Acetylation of PGK1 Promotes Liver Cancer Cell Proliferation and Tumorigenesis
英文论文题目: Acetylation of PGK1 Promotes Liver Cancer Cell Proliferation and Tumorigenesis
第一作者: Hu, HG; Zhu, WW; Qin, J; Chen, M; Gong, LY; Li, L; Liu, XY; Tao, YZ; Yin, HY; Zhou, H; Zhou, L; Ye, D; Ye, QH; Gao, D
英文第一作者: Hu, HG; Zhu, WW; Qin, J; Chen, M; Gong, LY; Li, L; Liu, XY; Tao, YZ; Yin, HY; Zhou, H; Zhou, L; Ye, D; Ye, QH; Gao, D
联系作者: Gao, D (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.
英文联系作者: Gao, D (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.
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发表年度: 2017
卷: 65
期: 2
页码: 515-528
摘要: Phosphoglycerate kinase 1 (PGK1) is an important enzyme in the metabolic glycolysis pathway. In this study, we observed a significant overexpression of PGK1 in liver cancer tissues and a negative correlation between PGK1 expression and liver cancer patient survival. Furthermore, depletion of PGK1 dramatically reduced cancer cell proliferation and tumorigenesis, indicating an oncogenic role of PGK1 in liver cancer progression. Moreover, we identified acetylation at the K323 site of PGK1 as an important regulatory mechanism for promoting its enzymatic activity and cancer cell metabolism. And we further characterized P300/cyclic adenosine monophosphate response element binding protein-binding protein-associated factor (PCAF) and Sirtuin 7 as the enzymes regulating K323 acetylation from both directions in liver cancer cells. Conclusion: These findings demonstrate a novel regulation of PGK1 as well as its important role in liver cancer progression.
英文摘要: Phosphoglycerate kinase 1 (PGK1) is an important enzyme in the metabolic glycolysis pathway. In this study, we observed a significant overexpression of PGK1 in liver cancer tissues and a negative correlation between PGK1 expression and liver cancer patient survival. Furthermore, depletion of PGK1 dramatically reduced cancer cell proliferation and tumorigenesis, indicating an oncogenic role of PGK1 in liver cancer progression. Moreover, we identified acetylation at the K323 site of PGK1 as an important regulatory mechanism for promoting its enzymatic activity and cancer cell metabolism. And we further characterized P300/cyclic adenosine monophosphate response element binding protein-binding protein-associated factor (PCAF) and Sirtuin 7 as the enzymes regulating K323 acetylation from both directions in liver cancer cells. Conclusion: These findings demonstrate a novel regulation of PGK1 as well as its important role in liver cancer progression.
刊物名称: HEPATOLOGY
英文刊物名称: HEPATOLOGY
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学科: Gastroenterology & Hepatology
英文学科: Gastroenterology & Hepatology
影响因子: 13.246
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论文类别: Article
英文论文类别: Article
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