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论文题目: Cell-matrix signals specify bone endothelial cells during developmental osteogenesis
英文论文题目: Cell-matrix signals specify bone endothelial cells during developmental osteogenesis
第一作者: Langen, UH; Pitulescu, ME; Kim, JM; Enriquez-Gasca, R; Sivaraj, KK; Kusumbe, AP; Singh, A; Di Russo, J; Bixel, MG; Zhou, B; Sorokin, L; Vaquerizas, JM; Adams, RH
英文第一作者: Langen, UH; Pitulescu, ME; Kim, JM; Enriquez-Gasca, R; Sivaraj, KK; Kusumbe, AP; Singh, A; Di Russo, J; Bixel, MG; Zhou, B; Sorokin, L; Vaquerizas, JM; Adams, RH
联系作者: Adams, RH (reprint author), Max Planck Inst Mol Biomed, Dept Tissue Morphogenesis, D-48149 Munster, Germany.
英文联系作者: Adams, RH (reprint author), Max Planck Inst Mol Biomed, Dept Tissue Morphogenesis, D-48149 Munster, Germany.
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发表年度: 2017
卷: 19
期: 3
页码: 189-201
摘要: Blood vessels in the mammalian skeletal system control bone formation and support haematopoiesis by generating local niche environments. While a specialized capillary subtype, termed type H, has been recently shown to couple angiogenesis and osteogenesis in adolescent, adult and ageing mice, little is known about the formation of specific endothelial cell populations during early developmental endochondral bone formation. Here, we report that embryonic and early postnatal long bone contains a specialized endothelial cell subtype, termed type E, which strongly supports osteoblast lineage cells and later gives rise to other endothelial cell subpopulations. The differentiation and functional properties of bone endothelial cells require cell-matrix signalling interactions. Loss of endothelial integrin beta 1 leads to endothelial cell differentiation defects and impaired postnatal bone growth, which is, in part, phenocopied by endothelial cell-specific laminin alpha 5 mutants. Our work outlines fundamental principles of vessel formation and endothelial cell differentiation in the developing skeletal system.
英文摘要: Blood vessels in the mammalian skeletal system control bone formation and support haematopoiesis by generating local niche environments. While a specialized capillary subtype, termed type H, has been recently shown to couple angiogenesis and osteogenesis in adolescent, adult and ageing mice, little is known about the formation of specific endothelial cell populations during early developmental endochondral bone formation. Here, we report that embryonic and early postnatal long bone contains a specialized endothelial cell subtype, termed type E, which strongly supports osteoblast lineage cells and later gives rise to other endothelial cell subpopulations. The differentiation and functional properties of bone endothelial cells require cell-matrix signalling interactions. Loss of endothelial integrin beta 1 leads to endothelial cell differentiation defects and impaired postnatal bone growth, which is, in part, phenocopied by endothelial cell-specific laminin alpha 5 mutants. Our work outlines fundamental principles of vessel formation and endothelial cell differentiation in the developing skeletal system.
刊物名称: NATURE CELL BIOLOGY
英文刊物名称: NATURE CELL BIOLOGY
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学科: Cell Biology
英文学科: Cell Biology
影响因子: 20.06
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论文类别: Article
英文论文类别: Article
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