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论文题目: Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention
英文论文题目: Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention
第一作者: Liu, RX; Hong, J; Xu, XQ; Feng, Q; Zhang, DY; Gu, YY; Shi, J; Zhao, SQ; Liu, W; Wang, XK; Xia, HH; Liu, ZP; Cui, B; Liang, PW; Xi, LQ; Jin, JB; Ying, XY; Wang, XL; Zhao, XJ; Li, WY; Jia, HJ; Lan, Z; Li, FY; Wang, R; Sun, YK; Yang, ML; Shen, YX; Jie, ZY; Li, JH; Chen, XM; Zhong, HZ; Xie, HL; Zhang, YF; Gu, WQ; Deng, XX; Shen, BY; Xu, X; Yang, HM; Xu, GW; Bi, YF; Lai, SH; Wang, J; Qi, L; Madsen, L; Wang, JQ; Ning, G; Kristiansen, K; Wang, WQ
英文第一作者: Liu, RX; Hong, J; Xu, XQ; Feng, Q; Zhang, DY; Gu, YY; Shi, J; Zhao, SQ; Liu, W; Wang, XK; Xia, HH; Liu, ZP; Cui, B; Liang, PW; Xi, LQ; Jin, JB; Ying, XY; Wang, XL; Zhao, XJ; Li, WY; Jia, HJ; Lan, Z; Li, FY; Wang, R; Sun, YK; Yang, ML; Shen, YX; Jie, ZY; Li, JH; Chen, XM; Zhong, HZ; Xie, HL; Zhang, YF; Gu, WQ; Deng, XX; Shen, BY; Xu, X; Yang, HM; Xu, GW; Bi, YF; Lai, SH; Wang, J; Qi, L; Madsen, L; Wang, JQ; Ning, G; Kristiansen, K; Wang, WQ
联系作者: Ning, G (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Lab Endocrinol & Metab, Shanghai, Peoples R China.
英文联系作者: Ning, G (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Lab Endocrinol & Metab, Shanghai, Peoples R China.
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发表年度: 2017
卷: 23
期: 7
页码: 859-+
摘要: Emerging evidence has linked the gut microbiome to human obesity. We performed a metagenome-wide association study and serum metabolomics profiling in a cohort of lean and obese, young, Chinese individuals. We identified obesity-associated gut microbial species linked to changes in circulating metabolites. The abundance of Bacteroides thetaiotaomicron, a glutamate-fermenting commensal, was markedly decreased in obese individuals and was inversely correlated with serum glutamate concentration. Consistently, gavage with B. thetaiotaomicron reduced plasma glutamate concentration and alleviated diet-induced body-weight gain and adiposity in mice. Furthermore, weight-loss intervention by bariatric surgery partially reversed obesity-associated microbial and metabolic alterations in obese individuals, including the decreased abundance of B. thetaiotaomicron and the elevated serum glutamate concentration. Our findings identify previously unknown links between intestinal microbiota alterations, circulating amino acids and obesity, suggesting that it may be possible to intervene in obesity by targeting the gut microbiota.
英文摘要: Emerging evidence has linked the gut microbiome to human obesity. We performed a metagenome-wide association study and serum metabolomics profiling in a cohort of lean and obese, young, Chinese individuals. We identified obesity-associated gut microbial species linked to changes in circulating metabolites. The abundance of Bacteroides thetaiotaomicron, a glutamate-fermenting commensal, was markedly decreased in obese individuals and was inversely correlated with serum glutamate concentration. Consistently, gavage with B. thetaiotaomicron reduced plasma glutamate concentration and alleviated diet-induced body-weight gain and adiposity in mice. Furthermore, weight-loss intervention by bariatric surgery partially reversed obesity-associated microbial and metabolic alterations in obese individuals, including the decreased abundance of B. thetaiotaomicron and the elevated serum glutamate concentration. Our findings identify previously unknown links between intestinal microbiota alterations, circulating amino acids and obesity, suggesting that it may be possible to intervene in obesity by targeting the gut microbiota.
刊物名称: NATURE MEDICINE
英文刊物名称: NATURE MEDICINE
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学科: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental
英文学科: Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental
影响因子: 29.886
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论文类别: Article
英文论文类别: Article
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