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姓 名:
肖友利
性    别:
专家类别:
青年千人计划/研究员
学 历:
博士研究生
所属部门:
植生生态所
学科类别:
化学生物学,酶学
电 话:
86-21-54924226
传 真:
电子邮件:
ylxiao@sibs.ac.cn
通讯地址:
枫林路300号

简历:
1996-2000年 山东大学化学学院,理学学士;
2000-2005年 中科院上海有机所, 理学博士;
2005年 通用电气全球研发中心(上海),主任工程师;
2006-2011 美国波士顿大学化学系,博士后助理研究员;
2012年 美国哈佛医学院,访问教授;
2012年 中科院上海生命科学院植生所,研究员。

研究方向:
实验室建设为化学和生物学的交叉学科研究特色,旨在利用化学生物学的手段探索生物质转化(分解和合成)及分子调节机制。主要研究方向包括:1)天然产物生物合成中关键的酶学机制和合成生物学方面的研究;2) 在环境和能源领域中,氧化还原(复杂)酶复合体催化的新颖反应;3) 化学小分子对重要生命现象的调节作用。

职称:

职务:

社会任职:

获奖及荣誉:
1999年 山东省“三好学生”称号
2000年 山东大学优秀毕业生及优秀毕业论文奖
2000年 中国科学院奖学金

代表论著:
1. Kelly Daughtry, Youli Xiao, Deborah Stoner-Ma, Eunsun Cho, Allen M. Orville*, Pinghua Liu*, and Karen N. Allen*. Quaternary Ammonium Oxidative Demethylation: X-ray Crystallographic, Resonance Raman and UV-visible Spectroscopic Analysis of a Rieske-type Demethylase. J. Am. Chem. Soc. 2012, 134, 2823-2834.
2. Youli Xiao, Wei-chen Chang, Hung-wen Liu*, Pinghua Liu*. Study of IspH, A Key Enzyme in the Methylerythritol Phosphate Pathway Using Fluoro-substituted Substrate Analogues. Organic Letter 2011, 13, 5912–5915.
3. Wei-chen Chang#, Youli Xiao#, (#equal contribution) Hung-wen Liu*, Pinghua Liu*. Mechanistic Studies of IspH-catalyzed Reaction Using Substrate Analogue: Implications for Substrate Binding and Protonation. Angewandte Chemie International Edition 2011, 50, 12304–12307.
4. Youli Xiao, Debra Rooker, Quincy You, Caren L. Freel Meyers, Pinghua Liu*. IspG-catalyzed Positional Isotopic Exchange in Methylerythritol Cyclodiphosphate of the Deoxyxylulose Phosphate Pathway: Mechanistic Implications. ChemBioChem 2011, 12, 527–530 (selected as Cover Paper).
5. Youli Xiao, Rodney L. Nyland II, Caren L. Freel Meyers, Pinghua Liu*. Methylerythritol Cyclodiphosphate (MEcPP) in Deoxyxylulose Phosphate Pathway: Synthesis from an Epoxide and Mechanisms. Chemical Communications, 2010, 46, 7220-7222.
6. Rodney L. Nyland II, Youli Xiao, Pinghua Liu,* Caren L. Freel Meyers*. IspG converts an epoxide substrate analog to (E)-4-hydroxy-3-methylbut-2-enyl diphosphate: implications for IspG catalysis in isoprenoid biosynthesis J. Am. Chem. Soc., 2009, 131, 17734-17735.
7. Youli Xiao, Georgia Zahariou, Yiannis Sanakis, Pinghua Liu*. IspG Enzyme Activity in the Deoxyxylulose Phosphate Pathway: Roles of the Iron匢甀氀昀甀爀 Cluster Biochemistry, 2009, 48, 10483-10485.
8. Youli Xiao, Lisa Chu, Yiannis Sanakis, Pinghua Liu*. Revisiting the IspH Catalytic System in the Deoxyxylulose Phosphate Pathway: Achieving High Activity. J. Am. Chem. Soc., 2009, 131,9931-9933.
9. Youli Xiao, Miranda Machacek, Kent Lee, Tomohisha Kuzuyama, and Pinghua Liu*. Prenyltransferase Substrate Binding Pocket Flexibility and Its Application in Isoprenoid Profiling. Molecular BioSystems 2009, 5, 913-917.
10. Youli Xiao, Pinghua Liu*. Synthesis of [1-13C] and Stereo-specifically [1-2H] Labeled Fluorinated Substrate Analogues of IspH Enzyme in the Deoxyxylulose Phosphate Pathway. Tetrahedron Letter, 2009, 50, 309-311.
11. Youli Xiao, Kent Lee, Pinghua Liu*. Synthesis of P-metlylase Substrates of the Bialaphos Biosynthetic Pathway. Organic Letter. 2008, 10, 5521-5524.
12. Youli Xiao, Pinghua Liu*. IspH Protein of the Deoxyxylulose Phosphate Pathway: Mechanistic Studies with C1 Deuterium Labeled Substrate and Fluorinated Analogue. Angew. Chem. Int. Ed., 2008, 47, 9722-9725.
13. Youli Xiao, Zongbao K. Zhao, Pinghua Liu*. Mechanistic Studies of IspH in the Deoxyxylulose Phosphate Pathway: Heterolytic C-O Bond Cleavage at C4 Position. J. Am. Chem. Soc., 2008, 130, 2164-2165.
14. Youli Xiao, Zheng Wang, Kuiling Ding*. Intramolecularly Dinuclear Magnesium Complex Catalyzed Copolymerization of Cyclohexene Oxide with CO2 under Ambient CO2 Pressure: Kinetics and Mechanism. Macromolecules, 2006, 39, 128-137.
15. Youli Xiao, Zheng Wang, Kuiling Ding*. Copolymerization of Cyclohexene Oxide with CO2 Using Intramolecularly Dinuclear Zinc Catalysts. Chem. – Eur. J. 2005, 11, 3668-3678.
 

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