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姓 名:
Andrew Teschendorff
性    别:
专家类别:
研究员
学 历:
博士研究生
所属部门:
计算生物所
学科类别:
计算生物学
电 话:
86-21-54920659
传 真:
54920451
电子邮件:
andrew@picb.ac.cn
通讯地址:
上海市徐汇区岳阳路320号生理大楼242室

简历:

1990.10--1995.07 英国爱丁堡大学 数学物理学 学士

1995.10--1996.07 英国剑桥大学 理论物理 硕士

1996.10--2000.05 英国剑桥大学 超弦理论 博士

2000.07--2001.07 英国电信公司实验室复杂性研究组

2001.09--2003.08 华威大学数学所 研究助理

2003.09--2008.08 剑桥研究所英国癌症研究 资深研究人员

2008.09--2013.09 伦敦大学学院癌症研究所 首席研究人员 

2013.10-至今    中科院-马普学会计算生物学伙伴研究所研究组长

研究方向:
计算系统基因组学

职称:
研究员

职务:
计算生物所研究组长、博士生导师

社会任职:

获奖及荣誉:
代表论著:

1.       Teschendorff AE, Li L, Yang Z. Denoising perturbation signatures reveals an actionable AKT-signaling gene module underlying a poor clinical outcome in endocrine treated ER+ breast cancer. Genome Biology 2015, 16:61.

2.       Banerji CR, Severini S, Caldas C, Teschendorff AE. Intra-Tumour Signalling Entropy Determines Clinical Outcome in Breast and Lung Cancer. PLoS Comput Biol 2015, 11(3):e1004115.

3.       Yuan T, Jiao Y, de Jong S, Ophoff RA, Beck S, Teschendorff AE. An Integrative Multi-scale Analysis of the Dynamic DNA Methylation Landscape in Aging. PLoS Genet 11(2):e1004996.

4.       Banerji, C. R., et al. (2015). "β-Catenin is central to DUX4-driven network rewiring in facioscapulohumeral muscular dystrophy." Journal of the Royal Society, Interface / the Royal Society 12(102): 20140797.

5.       Shen B, Teschendorff AE, Zhi D, Xia J. Biomedical data integration, modeling, and simulation in the era of big data and translational medicine. Biomed Res Int. 2014;2014:731546. doi: 10.1155/2014/731546. Epub 2014 Jul 24. PubMed PMID: 25147813; PubMed Central PMCID: PMC4131419.

6.       Anjum S, Fourkala EO, Zikan M, Wong A, Gentry-Maharaj A, Jones A, Hardy R, Cibula D, Kuh D, Jacobs IJ, Teschendorff AE, Menon U, Widschwendter M. A BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival. Genome Med. 2014 Jun 27;6(6):47. doi: 10.1186/gm567. eCollection 2014. PubMed PMID: 25067956; PubMed Central PMCID: PMC4110671.

7.       Gomez-Cabrero D, Abugessaisa I, Maier D, Teschendorff A, Merkenschlager M, Gisel A, Ballestar E, Bongcam-Rudloff E, Conesa A, Tegnér J. Data integration in the era of omics: current and future challenges. BMC Syst Biol. 2014;8 Suppl 2:I1. doi: 10.1186/1752-0509-8-S2-I1. Epub 2014 Mar 13. PubMed PMID: 25032990; PubMed Central PMCID: PMC4101704.

8.       Teschendorff AE, Liu X, Caren H, Pollard SM, Beck S, Widschwendter M, Chen L. The dynamics of DNA methylation covariation patterns in carcinogenesis. PLoS Comput Biol. 2014 Jul 10;10(7):e1003709. doi: 10.1371/journal.pcbi.1003709. eCollection 2014 Jul. PubMed PMID: 25010556; PubMed Central PMCID: PMC4091688.

9.       Ma Z, Teschendorff AE, Yu H, Taghia J, Guo J. Comparisons of non-Gaussian statistical models in DNA methylation analysis. Int J Mol Sci. 2014 Jun 16;15(6):10835-54. doi: 10.3390/ijms150610835. PubMed PMID: 24937687; PubMed Central PMCID: PMC4100184.

10.    Jiao Y, Widschwendter M, Teschendorff AE. A systems-level integrative framework for genome-wide DNA methylation and gene expression data identifies differential gene expression modules under epigenetic control. Bioinformatics. 2014 Aug 15;30(16):2360-6. doi: 10.1093/bioinformatics/btu316. Epub 2014 May 2. PubMed PMID: 24794928.

11.    Steegenga WT, Boekschoten MV, Lute C, Hooiveld GJ, de Groot PJ, Morris TJ, Teschendorff AE, Butcher LM, Beck S, Müller M. Genome-wide age-related changes in DNA methylation and gene expression in human PBMCs. Age (Dordr). 2014 Jun;36(3):9648. doi: 10.1007/s11357-014-9648-x. Epub 2014 May 2. PubMed PMID: 24789080; PubMed Central PMCID: PMC4082572.

12.    Teschendorff AE, Sollich P, Kuehn R. Signalling entropy: A novel network-theoretical framework for systems analysis and interpretation of functional omic data. Methods. 2014 Jun 1;67(3):282-93. doi: 10.1016/j.ymeth.2014.03.013. Epub 2014 Mar 24. PubMed PMID: 24675401.

13.    Pan S, Wu D, Teschendorff AE, Hong T, Wang L, Qian M, Wang C, Wang X. JAK2-centered interactome hotspot identified by an integrative network algorithm in acute Stanford type A aortic dissection. PLoS One. 2014 Feb 24;9(2):e89406. doi: 10.1371/journal.pone.0089406. eCollection 2014. PubMed PMID: 24586754; PubMed Central PMCID: PMC3933461.

14.    * Feber A, Guilhamon P, Lechner M, Fenton T, Wilson GA, Thirlwell C, Morris TJ, Flanagan AM, Teschendorff AE, Kelly JD, Beck S. Using high-density DNA methylation arrays to profile copy number alterations. Genome Biol. 2014 Feb 3;15(2):R30. doi: 10.1186/gb-2014-15-2-r30. PubMed PMID: 24490765; PubMed Central PMCID: PMC4054098.

承担科研项目情况:
 
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