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著作名称: 5′-3′ Exoribonucleases
著作名称英文: 5′-3′ Exoribonucleases
学科方向: 分子生物学
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编写人员: Tong L
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出版社英文: Springer
出版时间: 2012-09-08
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研究中心: 结构生物学与营养科学组,营养与代谢重点实验室
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The 5′-3′ exoribonucleases have important functions in RNA processing, RNA degradation, RNA interference, transcription, and other cellular processes. The Xrn1 and Xrn2/Rat1 family of enzymes are the best characterized 5′-3′ exoribonucleases, and there has been significant recent progress in the understanding of their structure and function. Especially, the first structural information on Rat1 just became available. Other 5′-3′ exoribonucleases have been identified recently, including yeast Rrp17 and B. subtilis RNase J1, the first enzyme with 5′-3′ exoribonuclease activity found in prokaryotes. This review will summarize our current understanding of these enzymes, focusing on their sequence conservation, molecular structure, biochemical and cellular functions.
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